Endocrine Abstracts

Evaluation of Laboratory Findings of Primary Hyperparathyroidism in Geriatric PatientsBackground: Primary hyperparathyroidism (PHPT) is an endocrine disease characterized by excessive secretion of parathormone (PTH) from one or more parathyroid glands. In recent studies, it has been reported that the PHPT clinic has turned into a largely asymptomatic disease in recent years. There are few studies on the effect of aging on laboratory find...

Introduction: Acromegaly is caused by growth hormone (GH) and insulin-like growth factor (IGF-1) excess and leads to various comorbidities. However, the association between acromegaly and thromboembolic diseases is unclear. Herein, we present a newly diagnosed acromegaly patient with massive pulmonary embolism.Case report: A 61-year-old female was hospitalized with acromegaly pre-diagnosis. She complained about extensive arthralgia and snoring. She had h...

Background: Hypoparathyroidism is an uncommon disorder of calcium metabolism characterized by hypocalcemia, hyperphosphatemia, and reduced level of parathyroid hormone (PTH). The most common cause of hypoparathyroidism is accidental damage to the parathyroid glands during thyroid surgery. There are no formal guidelines for hypoparathyroidism management. The main goal of treatment is to improve the symptoms of hypocalcemia, to keep the serum calcium within the low normal range,...

Background: Adrenocortical carcinoma (ACC) is a rare cancer that originates from the cortex of the adrenal gland. Although its exact etiology is not clear, it has been found to be associated with some hereditary cancer syndromes. Sometimes patients present with hormonal excess symptoms (virilization, Cushing’s syndrome) or local symptoms consistent with an abdominal mass. In ACC, computed tomography (CT) and magnetic resonance imaging (MRI) are preferred imaging modaliti...

Introduction: Wolfram syndrome, is a rare autosomal recessive genetic disorder that is characterized by diabetes mellitus (DM), diabetes insipidus (DI), optic atrophy, and sensorineural deafness as well as various other possible disorders. DM is the first manifestation, and optic atrophy also onsets in the first decade of life. The onsets of DI and sensorineural deafness are in the second decade, urinary tract abnormalities are in the third decade, and neurologic abnormalities...

Objective: Despite the publication of a recent meta-analysis of elastography in thyroid nodules, further work is necessary on this issue in different populations. In this study we aimed to evaluate the clinical value of elastography in nodular goiter in mild iodine defficient region without excluding according to nodule charecteristics.Materials and methods: This prospective study was conducted between April 2010 and December 2011 in Yildirim Beyazit Dis...

Objective: Hyperprolactinemia has been reported to be associated with abnormalities of glucose metabolism and cardiovascular inflammatory markers. However, the metabolic effects of high prolactin levels are not adequately clarified. The aims of this study were to evaluate the effects of hyperprolactinemia on endothelial function, insulin sensitivity and inflammatory markers in prolactinoma diagnosed subjects.Methods: In total, 58 hyperprolactinemic subje...

Objective: Nesfatin-1, was recently discovered in the brain which is derived from nucleobindin2 (NUCB2). Central and peripheral administration of nesfatin-1, inhibits food intake, dose-dependently. Hyperthyroid patients have increased appetite and food intake with a craving for carbohydrate-rich food, at the beginning of disease, but the physiological mechanisms underlying this behavior is not known exactly. In this study, we investigated whether nesfatin-1 is involved in the ...